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Target
G-protein coupled receptor 35
Ligand
BDBM50575546
Substrate
n/a
Meas. Tech.
ChEMBL_2125630 (CHEMBL4834975)
IC50
27±n/a nM
Citation
 Wei, L; Hou, T; Li, J; Zhang, X; Zhou, H; Wang, Z; Cheng, J; Xiang, K; Wang, J; Zhao, Y; Liang, X Structure-Activity Relationship Studies of Coumarin-like Diacid Derivatives as Human G Protein-Coupled Receptor-35 (hGPR35) Agonists and a Consequent New Design Principle. J Med Chem 64:2634-2647 (2021) [PubMed]  Article 
Target
Name:
G-protein coupled receptor 35
Synonyms:
G protein-coupled receptor 35 | GPR35 | GPR35_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
34085.57
Organism:
Homo sapiens (Human)
Description:
gi_33695097
Residue:
309
Sequence:
MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
  
Inhibitor
Name:
BDBM50575546
Synonyms:
CHEMBL4871203
Type:
Small organic molecule
Emp. Form.:
C21H12O9
Mol. Mass.:
408.3146
SMILES:
COc1ccccc1-c1c2oc(=O)c(cc2cc2cc(C(O)=O)c(=O)oc12)C(O)=O |(35.47,-5.72,;34.13,-6.49,;32.8,-5.73,;32.79,-4.19,;31.46,-3.42,;30.12,-4.21,;30.13,-5.74,;31.47,-6.5,;31.48,-8.04,;32.81,-8.8,;34.15,-8.03,;35.48,-8.8,;36.82,-8.04,;35.48,-10.35,;34.14,-11.12,;32.81,-10.35,;31.48,-11.12,;30.15,-10.35,;28.81,-11.12,;27.48,-10.34,;26.14,-11.1,;24.81,-10.33,;26.13,-12.64,;27.49,-8.79,;26.16,-8.02,;28.83,-8.03,;30.16,-8.81,;36.82,-11.13,;36.81,-12.67,;38.15,-10.36,)|
Structure:
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