Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50142093
Substrate
n/a
Meas. Tech.
ChEBML_49138
IC50
6.7±n/a nM
Citation
 Zhang, P; Bao, L; Zuckett, JF; Goldman, EA; Jia, ZJ; Arfsten, A; Edwards, S; Sinha, U; Hutchaleelaha, A; Park, G; Lambing, JL; Hollenbach, SJ; Scarborough, RM; Zhu, BY Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors incorporating substituted biphenyl P4 motifs. Bioorg Med Chem Lett 14:983-7 (2004) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50142093
Synonyms:
2'-Sulfamoyl-biphenyl-4-carboxylic acid [2-(5-chloro-pyridin-2-ylcarbamoyl)-phenyl]-amide | CHEMBL367609 | N-(2-(5-chloropyridin-2-ylcarbamoyl)phenyl)-2'-sulfamoylbiphenyl-4-carboxamide
Type:
Small organic molecule
Emp. Form.:
C25H19ClN4O4S
Mol. Mass.:
506.961
SMILES:
NS(=O)(=O)c1ccccc1-c1ccc(cc1)C(=O)Nc1ccccc1C(=O)Nc1ccc(Cl)cn1
Structure:
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