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Target
Envelope phospholipase F13
Ligand
BDBM50577059
Substrate
n/a
Meas. Tech.
ChEMBL_2128845 (CHEMBL4838274)
IC50
8980±n/a nM
Citation
 Shiryaev, VA; Skomorohov, MY; Leonova, MV; Bormotov, NI; Serova, OA; Shishkina, LN; Agafonov, AP; Maksyutov, RA; Klimochkin, YN Adamantane derivatives as potential inhibitors of p37 major envelope protein and poxvirus reproduction. Design, synthesis and antiviral activity. Eur J Med Chem 221:0 (2021) [PubMed]  Article 
Target
Name:
Envelope phospholipase F13
Synonyms:
3.1.1.- | 37 kDa protein | Envelope phospholipase F13 | OPG057 | PG057_VACCW | Palmitoylated EV membrane protein | p37K
Type:
PROTEIN
Mol. Mass.:
41798.24
Organism:
VACV
Description:
ChEMBL_118391
Residue:
372
Sequence:
MWPFASVPAGAKCRLVETLPENMDFRSDHLTTFECFNEIITLAKKYIYIASFCCNPLSTTRGALIFDKLKEASEKGIKIIVLLDERGKRNLGELQSHCPDINFITVNIDKKNNVGLLLGCFWVSDDERCYVGNASFTGGSIHTIKTLGVYSDYPPLATDLRRRFDTFKAFNSAKNSWLNLCSAACCLPVSTAYHIKNPIGGVFFTDSPEHLLGYSRDLDTDVVIDKLKSAKTSIDIEHLAIVPTTRVDGNSYYWPDIYNSIIEAAINRGVKIRLLVGNWDKNDVYSMATARSLDALCVQNDLSVKVFTIQNNTKLLIVDDEYVHITSANFDGTHYQNHGFVSFNSIDKQLVSEAKKIFERDWVSSHSKSLKI
  
Inhibitor
Name:
BDBM50577059
Synonyms:
CHEMBL4856490
Type:
Small organic molecule
Emp. Form.:
C19H22F3NO
Mol. Mass.:
337.3793
SMILES:
CC12CC3CC(C1)CC(C3)(C2)NC(=O)c1ccc(cc1)C(F)(F)F |TLB:9:8:4.3.2:6,THB:10:8:4:2.1.6,10:1:4:7.9.8,11:8:4:2.1.6,11:8:4.3.2:6,9:3:10.7.8:6,0:1:4:7.9.8|
Structure:
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