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Target
Serine/threonine-protein kinase 33
Ligand
BDBM8226
Substrate
n/a
Meas. Tech.
ChEMBL_2130023 (CHEMBL4839452)
IC50
17000±n/a nM
Citation
 Serafim, RAM; Sorrell, FJ; Berger, BT; Collins, RJ; Vasconcelos, SNS; Massirer, KB; Knapp, S; Bennett, J; Fedorov, O; Patel, H; Zuercher, WJ; Elkins, JM Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold. J Med Chem 64:13259-13278 (2021) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase 33
Synonyms:
STK33 | STK33_HUMAN | Serine/threonine-protein kinase 33
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57833.21
Organism:
Homo sapiens (Human)
Description:
gi_23943882
Residue:
514
Sequence:
MADSGLDKKSTKCPDCSSASQKDVLCVCSSKTRVPPVLVVEMSQTSSIGSAESLISLERKKEKNINRDITSRKDLPSRTSNVERKASQQQWGRGNFTEGKVPHIRIENGAAIEEIYTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVISAHDYSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQWLTGNKLSSVRPTNVLEMMKEWKNNPESVEENTTEEKNKPSTEEKLKSYQPWGNVPDANYTSDEEEEKQSTAYEKQFPATSKDNFDMCSSSFTSSKLLPAEIKGEMEKTPVTPSQGTATKYPAKSGALSRTKKKL
  
Inhibitor
Name:
BDBM8226
Synonyms:
3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione | 4-arylmaleimide deriv. 6i
Type:
Small organic molecule
Emp. Form.:
C17H13ClN2O3
Mol. Mass.:
328.75
SMILES:
COc1ccccc1C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O |c:9|
Structure:
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