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Target
Acyl-protein thioesterase 1
Ligand
BDBM50009366
Substrate
n/a
Meas. Tech.
ChEMBL_2133972 (CHEMBL4843582)
IC50
2.3±n/a nM
Citation
 ?imková, A; Ormsby, T; Sidej, N; Slav?tínská, LP; Brynda, J; Beranová, J; ?ácha, P; Majer, P; Konvalinka, J Structure-activity relationship and biochemical evaluation of novel fibroblast activation protein and prolyl endopeptidase inhibitors with ?-ketoamide warheads. Eur J Med Chem 224:0 (2021) [PubMed]  Article 
Target
Name:
Acyl-protein thioesterase 1
Synonyms:
Acyl-protein thioesterase 1/2 | Apt1 | LYPA1_RAT | Lypla1 | Lysosomal phospholipase A1
Type:
PROTEIN
Mol. Mass.:
24708.49
Organism:
Rattus norvegicus
Description:
ChEMBL_12731
Residue:
230
Sequence:
MCGNNMSAPMPAVVPAARKATAAVIFLHGLGDTGHGWAEAFAGIKSSHIKYICPHAPVMPVTLNMSMMMPSWFDIIGLSPDSQEDESGIKQAAETVKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFSQGPINSANRDISVLQCHGDCDPLVPLMFGSLTVERLKGLVNPANVTFKVYEGMMHSSCQQEMMDVKYFIDKLLPPID
  
Inhibitor
Name:
BDBM50009366
Synonyms:
CHEMBL3233842 | US11504364, Compound Ref.-Comp. | US9346814, Cmpd No 1, Example 1
Type:
Small organic molecule
Emp. Form.:
C17H14F2N4O2
Mol. Mass.:
344.3155
SMILES:
FC1(F)C[C@@H](C#N)N(C1)C(=O)CNC(=O)c1ccnc2ccccc12 |r|
Structure:
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