Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50148107
Substrate
n/a
Meas. Tech.
ChEMBL_154193 (CHEMBL760000)
EC50
2800±n/a nM
Citation
Koyama, H; Miller, DJ; Boueres, JK; Desai, RC; Jones, AB; Berger, JP; MacNaul, KL; Kelly, LJ; Doebber, TW; Wu, MS; Zhou, G; Wang, PR; Ippolito, MC; Chao, YS; Agrawal, AK; Franklin, R; Heck, JV; Wright, SD; Moller, DE; Sahoo, SP (2R)-2-ethylchromane-2-carboxylic acids: discovery of novel PPARalpha/gamma dual agonists as antihyperglycemic and hypolipidemic agents. J Med Chem 47:3255-63 (2004) [PubMed] Article
More Info.:
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Human
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
Inhibitor
Name:
BDBM50148107
Synonyms:
2-Ethyl-7-{3-[4-(4-methanesulfonyl-phenoxy)-2-propyl-phenoxy]-propoxy}-chroman-2-carboxylic acid | CHEMBL113324
Type:
Small organic molecule
Emp. Form.:
C31H36O8S
Mol. Mass.:
568.678
SMILES:
CCCc1cc(Oc2ccc(cc2)S(C)(=O)=O)ccc1OCCCOc1ccc2CCC(CC)(Oc2c1)C(O)=O