Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50149670
Substrate
n/a
Meas. Tech.
ChEMBL_302831 (CHEMBL838621)
Ki
0.8±n/a nM
Citation
 Huang, CQ; Wilcoxen, KM; Grigoriadis, DE; McCarthy, JR; Chen, C Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists. Bioorg Med Chem Lett 14:3943-7 (2004) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Human
Description:
P34998
Residue:
415
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50149670
Synonyms:
CHEMBL361782 | [3-(3-Chloro-5-trifluoromethyl-pyridin-2-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-cyclopropylmethyl-propyl-amine
Type:
Small organic molecule
Emp. Form.:
C21H23ClF3N5
Mol. Mass.:
437.889
SMILES:
CCCN(CC1CC1)c1cc(C)nc2c(c(C)nn12)-c1ncc(cc1Cl)C(F)(F)F |(3.73,6.08,;4.32,4.66,;3.39,3.42,;3.97,2,;5.49,1.81,;6.09,.37,;7.31,-.56,;5.89,-1.15,;3.04,.79,;3.62,-.64,;2.68,-1.85,;3.27,-3.27,;1.15,-1.64,;.59,-.22,;-.86,.27,;-.83,1.81,;-2.05,2.75,;.66,2.24,;1.52,.97,;-2.26,-.38,;-2.26,-1.94,;-3.59,-2.71,;-4.92,-1.94,;-4.92,-.4,;-3.59,.37,;-3.61,1.93,;-6.27,-2.71,;-7.48,-3.41,;-7.77,-2.13,;-6.53,-4.3,)|
Structure:
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