Reaction Details Report a problem with these data
Target
Melanocortin receptor 3
Ligand
BDBM50152799
Substrate
n/a
Meas. Tech.
ChEMBL_303253 (CHEMBL826379)
Ki
2000±n/a nM
Citation
 Pontillo, J; Tran, JA; Arellano, M; Fleck, BA; Huntley, R; Marinkovic, D; Lanier, M; Nelson, J; Parker, J; Saunders, J; Tucci, FC; Jiang, W; Chen, CW; White, NS; Foster, AC; Chen, C Structure-activity relationships of piperazinebenzylamines as potent and selective agonists of the human melanocortin-4 receptor. Bioorg Med Chem Lett 14:4417-23 (2004) [PubMed]  Article 
Target
Name:
Melanocortin receptor 3
Synonyms:
MC3-R | MC3R | MC3R_HUMAN | Melanocortin MC3 | Melanocortin receptor (M3 and M4)
Type:
Enzyme
Mol. Mass.:
36044.86
Organism:
Homo sapiens (Human)
Description:
P41968
Residue:
323
Sequence:
MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG
  
Inhibitor
Name:
BDBM50152799
Synonyms:
(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[1-(piperidin-3-ylamino)-ethyl]-phenyl}-piperazin-1-yl)-ethyl]-amide | (R)-N-((R)-3-(4-chlorophenyl)-1-oxo-1-(4-(2-(1-(piperidin-3-ylamino)ethyl)phenyl)piperazin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | 1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[1-(piperidin-3-ylamino)-ethyl]-phenyl}-piperazin-1-yl)-ethyl]-amide | CHEMBL360716
Type:
Small organic molecule
Emp. Form.:
C36H45ClN6O2
Mol. Mass.:
629.235
SMILES:
CC(NC1CCCNC1)c1ccccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1
Structure:
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