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Target
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Ligand
BDBM50585529
Substrate
n/a
Meas. Tech.
ChEMBL_2162607 (CHEMBL5047468)
Ki
4800±n/a nM
Citation
 Medellin, B; Yang, W; Konduri, S; Dong, J; Irani, S; Wu, H; Matthews, WL; Zhang, ZY; Siegel, D; Zhang, Y Targeted Covalent Inhibition of Small CTD Phosphatase 1 to Promote the Degradation of the REST Transcription Factor in Human Cells. J Med Chem 65:507-519 (2022) [PubMed]  Article 
Target
Name:
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Synonyms:
CTDS1_HUMAN | CTDSP1 | NIF3 | NLIIF | SCP1 | carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29199.89
Organism:
Homo sapiens (Human)
Description:
gi_10864009
Residue:
261
Sequence:
MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
  
Inhibitor
Name:
BDBM50585529
Synonyms:
CHEMBL5077686
Type:
Small organic molecule
Emp. Form.:
C19H17F3N2O6S2
Mol. Mass.:
490.473
SMILES:
FC(F)(F)Oc1ccc(cc1)S(=O)(=O)NCCCNC(=O)C1=Cc2ccccc2S1(=O)=O |t:22|
Structure:
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