Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50074364
Substrate
n/a
Meas. Tech.
ChEMBL_303621 (CHEMBL828876)
Ki
18±n/a nM
Citation
 Dzierba, CDTakvorian, AGRafalski, MKasireddy-Polam, PWong, HMolski, TFZhang, GLi, YWLelas, SPeng, YMcElroy, JFZaczek, RCTaub, RACombs, APGilligan, PJTrainor, GL Synthesis, structure-activity relationships, and in vivo properties of 3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-ones as corticotropin-releasing factor-1 receptor antagonists. J Med Chem 47:5783-90 (2004) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Human
Description:
P34998
Residue:
415
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50074364
Synonyms:
CHEMBL350356 | N*2*-(2-Bromo-4-isopropyl-phenyl)-N*4*-butyl-N*2*,N*4*-diethyl-6-methyl-pyrimidine-2,4-diamine
Type:
Small organic molecule
Emp. Form.:
C22H33BrN4
Mol. Mass.:
433.428
SMILES:
CCCCN(CC)c1cc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)C
Structure:
Search PDB for entries with ligand similarity: