Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50035097
Substrate
n/a
Meas. Tech.
ChEMBL_2184652 (CHEMBL5096734)
Ki
2.0±n/a nM
Citation
 Hiesinger, K; Dar'in, D; Proschak, E; Krasavin, M Spirocyclic Scaffolds in Medicinal Chemistry. J Med Chem 64:150-183 (2021) [PubMed] 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Guinea pig
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50035097
Synonyms:
1''-benzyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-piperidine](L-687,384) | 1''-benzyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-piperidine]; HCl | 1''-benzylspiro[1,2,3,4-tetrahydronaphthalene-1,4''-(hexahydropyridine)] | 1'-benzylspiro[1,2,3,4-tetrahydronaphthalene-1,4'-(hexahydropyridine)](L-687,384) | CHEMBL1256916 | CHEMBL303336 | L-687384
Type:
Small organic molecule
Emp. Form.:
C21H25N
Mol. Mass.:
291.4299
SMILES:
C(N1CCC2(CCCc3ccccc23)CC1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: