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Target
Cytochrome P450 4B1
Ligand
BDBM50365230
Substrate
n/a
Meas. Tech.
ChEMBL_2192069 (CHEMBL5104429)
IC50
>24000±n/a nM
Citation
 Madhav, H; Hoda, N An insight into the recent development of the clinical candidates for the treatment of malaria and their target proteins. Eur J Med Chem 210:0 (2021) [PubMed] 
Target
Name:
Cytochrome P450 4B1
Synonyms:
1.14.14.1 | CP4B1_HUMAN | CYP4B1 | CYPIVB1 | Cytochrome P450 4B1 | Cytochrome P450-HP
Type:
PROTEIN
Mol. Mass.:
59005.59
Organism:
Homo sapiens
Description:
ChEMBL_119703
Residue:
511
Sequence:
MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK
  
Inhibitor
Name:
BDBM50365230
Synonyms:
CHEMBL1956285 | US11903936, Compound DSM265 | US9238653, Table 5, Compound 10
Type:
Small organic molecule
Emp. Form.:
C14H12F7N5S
Mol. Mass.:
415.332
SMILES:
Cc1cc(Nc2ccc(cc2)S(F)(F)(F)(F)F)n2nc(nc2n1)C(C)(F)F
Structure:
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