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Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM50160916
Substrate
n/a
Meas. Tech.
ChEMBL_302785 (CHEMBL839470)
Ki
260±n/a nM
Citation
 Ducharme, Y; Blouin, M; Carrière, MC; Chateauneuf, A; Côté, B; Denis, D; Frenette, R; Greig, G; Kargman, S; Lamontagne, S; Martins, E; Nantel, F; O'Neill, G; Sawyer, N; Metters, KM; Friesen, RW 2,3-Diarylthiophenes as selective EP1 receptor antagonists. Bioorg Med Chem Lett 15:1155-60 (2005) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
PE2R1_HUMAN | PGE receptor, EP1 subtype | PTGER1 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP1 subtype | Prostaglandin E2 receptor EP1 subtype (EP1) | Prostanoid EP1 receptor
Type:
Enzyme
Mol. Mass.:
41834.57
Organism:
Homo sapiens (Human)
Description:
P34995
Residue:
402
Sequence:
MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
  
Inhibitor
Name:
BDBM50160916
Synonyms:
2-{5-[3-(2-Benzyloxy-5-chloro-phenyl)-thiophen-2-yl]-pyridin-3-yl}-1,1,1,3,3,3-hexafluoro-propan-2-ol | CHEMBL182367
Type:
Small organic molecule
Emp. Form.:
C25H16ClF6NO2S
Mol. Mass.:
543.908
SMILES:
OC(c1cncc(c1)-c1sccc1-c1cc(Cl)ccc1OCc1ccccc1)(C(F)(F)F)C(F)(F)F
Structure:
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