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Target
Dual specificity protein kinase CLK2
Ligand
BDBM50592248
Substrate
n/a
Meas. Tech.
ChEMBL_2203516 (CHEMBL5116224)
IC50
20±n/a nM
Citation
 El-Gamil, DS; ElHady, AK; Chen, PJ; Hwang, TL; Abadi, AH; Abdel-Halim, M; Engel, M Development of novel conformationally restricted selective Clk1/4 inhibitors through creating an intramolecular hydrogen bond involving an imide linker. Eur J Med Chem 238:0 (2022) [PubMed] 
Target
Name:
Dual specificity protein kinase CLK2
Synonyms:
2.7.12.1 | CDC-like kinase 2 | CDC-like kinase 2 (CLK2) | CDC2-like kinase 2 (CLK2) | CLK2 | CLK2_HUMAN
Type:
n/a
Mol. Mass.:
60128.79
Organism:
Human
Description:
P49760
Residue:
499
Sequence:
MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR
  
Inhibitor
Name:
BDBM50592248
Synonyms:
CHEMBL5178079
Type:
Small organic molecule
Emp. Form.:
C22H16N4O
Mol. Mass.:
352.3886
SMILES:
CC1N=CC(=N1)c1ccc2occ(-c3cccc(c3)-c3ccncc3)c2n1 |c:2,4|
Structure:
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