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Target
Orexin receptor type 2
Ligand
BDBM50592801
Substrate
n/a
Meas. Tech.
ChEMBL_2205645 (CHEMBL5118353)
IC50
>10000±n/a nM
Citation
 Saitoh, T; Amezawa, M; Horiuchi, J; Nagumo, Y; Yamamoto, N; Kutsumura, N; Ohshita, R; Tokuda, A; Irukayama-Tomobe, Y; Ogawa, Y; Ishikawa, Y; Hasegawa, E; Sakurai, T; Uchida, Y; Sato, T; Gouda, H; Tanimura, R; Yanagisawa, M; Nagase, H Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library. Eur J Med Chem 240:0 (2022) [PubMed] 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM50592801
Synonyms:
CHEMBL5173055
Type:
Small organic molecule
Emp. Form.:
C38H41N5O5
Mol. Mass.:
647.7626
SMILES:
[H][C@]12CO[C@]3([H])N1[C@@]([H])(O[C@]3(C)c1cccc(NC(=O)c3ccc(cc3)N(C)C)c1)[C@](C)(O2)c1cccc(NC(=O)c2ccc(cc2)N(C)C)c1 |r|
Structure:
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