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Target
Cathepsin K
Ligand
BDBM50163832
Substrate
n/a
Meas. Tech.
ChEMBL_302329 (CHEMBL875194)
Ki
1.8±n/a nM
Citation
 Barrett, DG; Deaton, DN; Hassell, AM; McFadyen, RB; Miller, AB; Miller, LR; Payne, JA; Shewchuk, LM; Willard, DH; Wright, LL Acyclic cyanamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett 15:3039-43 (2005) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Human
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50163832
Synonyms:
(1S)-2-cyclohexyl-1-methylethyl (2S)-1-cyanopyrrolidine-2-carboxylate | (2S)-1-cyclohexylpropan-2-yl 1-cyanopyrrolidine-2-carboxylate | CHEMBL180839
Type:
Small organic molecule
Emp. Form.:
C15H24N2O2
Mol. Mass.:
264.3633
SMILES:
C[C@@H](CC1CCCCC1)OC(=O)C1CCCN1C#N
Structure:
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