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Target
Tyrosine-protein phosphatase non-receptor type 6
Ligand
BDBM50594490
Substrate
n/a
Meas. Tech.
ChEMBL_2213086 (CHEMBL5126035)
IC50
200000±n/a nM
Citation
 Yao, FH; Liang, X; Lu, XH; Cheng, X; Luo, LX; Qi, SH Pyrrospirones K-Q, Decahydrofluorene-Class Alkaloids from the Marine-Derived Fungus  J Nat Prod 85:2071-2081 (2022) [PubMed] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 6
Synonyms:
HCP | PTN6_HUMAN | PTP1C | PTPN6 | Protein tyrosine phosphatase SHP-1 (SHP-1) | Protein-tyrosine phosphatase 1C | Protein-tyrosine phosphatase SHP-1 | Src homology phosphatase 1 (SHP-1) | Tyrosine-protein phosphatase non-receptor type 6 | Tyrosine-protein phosphatase non-receptor type 6 (SHP1)
Type:
Protein
Mol. Mass.:
67570.41
Organism:
Homo sapiens (Human)
Description:
P29350
Residue:
595
Sequence:
MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
  
Inhibitor
Name:
BDBM50594490
Synonyms:
CHEMBL5192054
Type:
Small organic molecule
Emp. Form.:
C32H41NO5
Mol. Mass.:
519.6716
SMILES:
[H][C@]12[C@@H]3Oc4ccc(CC5NC(=O)[C@@]6(C[C@H](O)[C@@](C)(C=C(C)[C@@]1([H])[C@]1(C)C[C@H](C)C[C@H](C)[C@@]31[H])[C@]2([H])C6=O)[C@@H]5O)cc4 |r,t:19|
Structure:
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