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Target
Tyrosine-protein phosphatase non-receptor type 2
Ligand
BDBM50594493
Substrate
n/a
Meas. Tech.
ChEMBL_2213089 (CHEMBL5126038)
IC50
14000±n/a nM
Citation
 Yao, FH; Liang, X; Lu, XH; Cheng, X; Luo, LX; Qi, SH Pyrrospirones K-Q, Decahydrofluorene-Class Alkaloids from the Marine-Derived Fungus  J Nat Prod 85:2071-2081 (2022) [PubMed] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 2
Synonyms:
PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP)
Type:
Protein
Mol. Mass.:
48481.80
Organism:
Homo sapiens (Human)
Description:
P17706
Residue:
415
Sequence:
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
  
Inhibitor
Name:
BDBM50594493
Synonyms:
CHEMBL4757140
Type:
Small organic molecule
Emp. Form.:
C32H39NO4
Mol. Mass.:
501.6564
SMILES:
[H][C@]12[C@H](Cc3ccc(O[C@@H]4[C@]5([H])[C@@H](C)C[C@@H](C)C[C@@]5(C)[C@]5([H])C(C)=C[C@](C)(C=C)[C@]([H])(C1=O)[C@@]45[H])cc3)C(=O)NC2=O |r,c:24|
Structure:
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