Reaction Details Report a problem with these data
Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Ligand
BDBM50595087
Substrate
n/a
Meas. Tech.
ChEMBL_2215386 (CHEMBL5128518)
IC50
100±n/a nM
Citation
 Wang, Y; Chen, H; Zha, X Overview of SIRT5 as a potential therapeutic target: Structure, function and inhibitors. Eur J Med Chem 236:0 (2022) [PubMed] 
Target
Name:
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Synonyms:
NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3
Type:
Protein
Mol. Mass.:
43582.69
Organism:
Homo sapiens (Human)
Description:
Q9NTG7
Residue:
399
Sequence:
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
  
Inhibitor
Name:
BDBM50595087
Synonyms:
CHEMBL5192844
Type:
Small organic molecule
Emp. Form.:
C18H22N8O4S2
Mol. Mass.:
478.548
SMILES:
CCn1c2nc(SSc3nc4n(CC)c(=O)n(CC)c(=O)c4[nH]3)[nH]c2c(=O)n(CC)c1=O
Structure:
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