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Target
Sodium-dependent phosphate transport protein 2B
Ligand
BDBM50596527
Substrate
n/a
Meas. Tech.
ChEMBL_2220647 (CHEMBL5133981)
IC50
7.6±n/a nM
Citation
 Ushiki, Y; Kawabe, K; Yamamoto-Okada, K; Uneuchi, F; Asanuma, Y; Yamaguchi, C; Ohta, H; Shibata, T; Abe, T; Okumura-Kitajima, L; Kosai, Y; Endo, M; Otake, K; Munetomo, E; Takahashi, T; Kakinuma, H Design, synthesis and biological evaluation of novel 1H-pyrazole-4-carbonyl-4,5,6,7-tetrahydrobenzo [b]thiophene derivatives as gut-selective NaPi2b inhibitors. Bioorg Med Chem Lett 59:0 (2022) [PubMed] 
Target
Name:
Sodium-dependent phosphate transport protein 2B
Synonyms:
NPT2B_RAT | Na(+)-dependent phosphate cotransporter 2B | Na(+)/Pi cotransporter 2B | NaPi-2b | Slc34a2 | Sodium-phosphate transport protein 2B | Sodium/phosphate cotransporter 2B | Solute carrier family 34 member 2 | rNaPi IIb
Type:
PROTEIN
Mol. Mass.:
75997.72
Organism:
Rattus norvegicus
Description:
ChEMBL_120738
Residue:
695
Sequence:
MAPWPELENAHPNPNKFIEGASGPQSSIPDKDKGTSKTNDSGTPVAKIELLPSYSALVLIEEPPEGNDPWDLPELQDNGIKWSERDSKGKILCIFQGIGKFILLLGFLYLFVCSLDVLSSAFQLVGGKMAGQFFSNNSIMSNPVAGLVIGVLVTVMVQSSSTSSSIIVSMVASSLLSVRAAIPIIMGANIGTSITNTIVALMQAGDRNEFRRAFAGATVHDFFNWLSVLVLLPLEAATHYLEKLTNLVLETFSFQNGEDAPDILKVITDPFTKLIIQLDKKVIQQIAMGDSEAQNKSLIKIWCKTISNVIEENVTVPSPDNCTSPSYCWTDGIQTWTIQNVTEKENIAKCQHIFVNFSLPDLAVGIILLTVSLLILCGCLIMIVKLLGSVLRGQVATVIKKTLNTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSAMTPLIGIGVISIERAYPLTLGSNIGTTTTAILAALASPGNTLRSSLQIALCHFFFNISGILLWYPIPFTRLPIRLAKGLGNISAKYRWFAVFYLIFFFLLTPLTVFGLSLAGWPVLVGVGVPIILLILLVLCLRMLQARCPRILPLKLRDWNFLPLWMHSLKPWDNIISLATSCFQRRCCCCCRVCCRVCCMVCGCKCCRCSKCCKNLEEEEKEQDVPVKASGGFDNTAMSKECQDEGKGQVEVLGMKALSNTTVF
  
Inhibitor
Name:
BDBM50596527
Synonyms:
CHEMBL5195035
Type:
Small organic molecule
Emp. Form.:
C49H64ClF3N8O5S
Mol. Mass.:
969.596
SMILES:
CCC(CC)N(CCN(C)C(=O)CCC(=O)NC(C)(C)C(=O)NCCN(C)C)Cc1cccc(c1)C(=O)Nc1sc2CC(C)(C)CCc2c1C(=O)c1cnn(c1)-c1ccc(Cl)c(c1)C(F)(F)F
Structure:
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