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Target
Triosephosphate isomerase, glycosomal
Ligand
BDBM50332795
Substrate
n/a
Meas. Tech.
ChEMBL_2224917 (CHEMBL5138430)
IC50
3500±n/a nM
Citation
 Beltran-Hortelano, I; Alcolea, V; Font, M; Pérez-Silanes, S Examination of multiple Trypanosoma cruzi targets in a new drug discovery approach for Chagas disease. Bioorg Med Chem 58:0 (2022) [PubMed] 
Target
Name:
Triosephosphate isomerase, glycosomal
Synonyms:
TIM | TPIS_TRYCR | Triose-phosphate isomerase
Type:
PROTEIN
Mol. Mass.:
27334.70
Organism:
Trypanosoma cruzi
Description:
ChEMBL_596695
Residue:
251
Sequence:
MASKPQPIAAANWKCNGSESLLVPLIETLNAATFDHDVQCVVAPTFLHIPMTKARLTNPKFQIAAQNAITRSGAFTGEVSLQILKDYGISWVVLGHSERRLYYGETNEIVAEKVAQACAAGFHVIVCVGETNEEREAGRTAAVVLTQLAAVAQKLSKEAWSRVVIAYEPVWAIGTGKVATPQQAQEVHELLRRWVRSKLGTDIAAQLRILYGGSVTAKNARTLYQMRDINGFLVGGASLKPEFVEIIEATK
  
Inhibitor
Name:
BDBM50332795
Synonyms:
3-(4-methylphenyl)-5-oxo-4,5-dihydro-1,2,4-thiadiazole | 3-p-tolyl-1,2,4-thiadiazol-5(4H)-one | CHEMBL258634
Type:
Small organic molecule
Emp. Form.:
C9H8N2OS
Mol. Mass.:
192.238
SMILES:
Cc1ccc(cc1)-c1nc(=O)s[nH]1
Structure:
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