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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50175752
Substrate
n/a
Meas. Tech.
ChEMBL_328205 (CHEMBL863917)
IC50
1.6±n/a nM
Citation
 Bao, J; Hunt, JA; Miao, S; Rupprecht, KM; Stelmach, JE; Liu, L; Ruzek, RD; Sinclair, PJ; Pivnichny, JV; Hop, CE; Kumar, S; Zaller, DM; Shoop, WL; O'neill, EA; O'keefe, SJ; Thompson, CM; Cubbon, RM; Wang, R; Zhang, WX; Thompson, JE; Doherty, JB p38 MAP kinase inhibitors: metabolically stabilized piperidine-substituted quinolinones and naphthyridinones. Bioorg Med Chem Lett 16:64-8 (2005) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50175752
Synonyms:
7-(1-tert-butylpiperidin-4-yloxy)-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)quinolin-2(1H)-one | CHEMBL199707
Type:
Small organic molecule
Emp. Form.:
C30H29Cl3N2O2
Mol. Mass.:
555.922
SMILES:
CC(C)(C)N1CCC(CC1)Oc1cc(-c2ccccc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 |(6.9,-20.6,;5.57,-19.84,;4.8,-21.17,;6.35,-18.51,;4.24,-19.07,;2.9,-19.84,;1.57,-19.07,;1.56,-17.53,;2.9,-16.75,;4.24,-17.53,;.23,-16.76,;-1.1,-17.54,;-1.1,-19.09,;-2.43,-19.86,;-2.43,-21.4,;-3.77,-22.16,;-3.77,-23.7,;-2.44,-24.47,;-1.1,-23.7,;-1.1,-22.16,;.23,-21.39,;-3.77,-19.09,;-5.1,-19.87,;-6.44,-19.09,;-6.44,-17.55,;-7.77,-16.77,;-5.1,-16.78,;-5.1,-15.24,;-6.43,-14.48,;-7.76,-15.25,;-6.43,-12.94,;-5.09,-12.17,;-3.76,-12.94,;-3.76,-14.48,;-2.43,-15.25,;-3.77,-17.54,;-2.44,-16.77,)|
Structure:
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