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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50175754
Substrate
n/a
Meas. Tech.
ChEMBL_328206 (CHEMBL863945)
IC50
2.4±n/a nM
Citation
 Bao, J; Hunt, JA; Miao, S; Rupprecht, KM; Stelmach, JE; Liu, L; Ruzek, RD; Sinclair, PJ; Pivnichny, JV; Hop, CE; Kumar, S; Zaller, DM; Shoop, WL; O'neill, EA; O'keefe, SJ; Thompson, CM; Cubbon, RM; Wang, R; Zhang, WX; Thompson, JE; Doherty, JB p38 MAP kinase inhibitors: metabolically stabilized piperidine-substituted quinolinones and naphthyridinones. Bioorg Med Chem Lett 16:64-8 (2005) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50175754
Synonyms:
7-(1-tert-butylpiperidin-4-yloxy)-5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)quinolin-2(1H)-one | CHEMBL381201
Type:
Small organic molecule
Emp. Form.:
C30H28Cl3FN2O2
Mol. Mass.:
573.913
SMILES:
CC(C)(C)N1CCC(CC1)Oc1cc(-c2ccc(F)cc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 |(7.47,-2.3,;6.15,-1.54,;5.38,-2.87,;6.92,-.21,;4.81,-.77,;3.48,-1.54,;2.15,-.77,;2.14,.77,;3.47,1.55,;4.81,.77,;.8,1.54,;-.53,.76,;-.52,-.79,;-1.86,-1.56,;-1.86,-3.1,;-3.19,-3.86,;-3.19,-5.4,;-1.86,-6.17,;-1.86,-7.71,;-.52,-5.4,;-.53,-3.86,;.8,-3.09,;-3.19,-.79,;-4.52,-1.57,;-5.86,-.79,;-5.86,.75,;-7.2,1.52,;-4.52,1.52,;-4.52,3.06,;-5.85,3.82,;-7.18,3.05,;-5.86,5.36,;-4.52,6.13,;-3.18,5.36,;-3.19,3.82,;-1.85,3.05,;-3.19,.75,;-1.86,1.52,)|
Structure:
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