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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50175748
Substrate
n/a
Meas. Tech.
ChEMBL_328205 (CHEMBL863917)
IC50
0.61±n/a nM
Citation
 Bao, J; Hunt, JA; Miao, S; Rupprecht, KM; Stelmach, JE; Liu, L; Ruzek, RD; Sinclair, PJ; Pivnichny, JV; Hop, CE; Kumar, S; Zaller, DM; Shoop, WL; O'neill, EA; O'keefe, SJ; Thompson, CM; Cubbon, RM; Wang, R; Zhang, WX; Thompson, JE; Doherty, JB p38 MAP kinase inhibitors: metabolically stabilized piperidine-substituted quinolinones and naphthyridinones. Bioorg Med Chem Lett 16:64-8 (2005) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50175748
Synonyms:
5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-(8-methyl-8-aza-bicyclo[3.2.1]octan-3-yl)quinolin-2(1H)-one | CHEMBL200093
Type:
Small organic molecule
Emp. Form.:
C29H24Cl3FN2O
Mol. Mass.:
541.871
SMILES:
CN1C2CCC1CC(C2)c1cc(-c2ccc(F)cc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 |THB:9:7:1:3.4,(34.88,5.72,;33.46,5.13,;31.9,5.09,;30.71,6.25,;31.25,4.99,;32.49,4.2,;32.27,2.46,;30.7,2.41,;31.64,3.27,;29.37,1.64,;29.38,.09,;28.04,-.68,;28.05,-2.22,;26.71,-2.98,;26.71,-4.52,;28.04,-5.29,;28.04,-6.83,;29.38,-4.52,;29.37,-2.98,;30.7,-2.21,;26.71,.09,;25.38,-.69,;24.04,.09,;24.04,1.63,;22.71,2.4,;25.38,2.4,;25.38,3.93,;24.05,4.7,;22.72,3.93,;24.05,6.23,;25.39,7.01,;26.72,6.24,;26.72,4.7,;28.05,3.93,;26.71,1.63,;28.04,2.4,)|
Structure:
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