Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 14
Ligand
BDBM50175744
Substrate
n/a
Meas. Tech.
ChEMBL_328205 (CHEMBL863917)
IC50
1.15±n/a nM
Citation
Bao, J; Hunt, JA; Miao, S; Rupprecht, KM; Stelmach, JE; Liu, L; Ruzek, RD; Sinclair, PJ; Pivnichny, JV; Hop, CE; Kumar, S; Zaller, DM; Shoop, WL; O'neill, EA; O'keefe, SJ; Thompson, CM; Cubbon, RM; Wang, R; Zhang, WX; Thompson, JE; Doherty, JB p38 MAP kinase inhibitors: metabolically stabilized piperidine-substituted quinolinones and naphthyridinones. Bioorg Med Chem Lett 16:64-8 (2005) [PubMed] Article
More Info.:
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
Inhibitor
Name:
BDBM50175744
Synonyms:
7-(1-tert-butyl-1,2,3,6-tetrahydropyridin-4-yl)-5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)quinolin-2(1H)-one | CHEMBL199593
Type:
Small organic molecule
Emp. Form.:
C30H26Cl3FN2O
Mol. Mass.:
555.898
SMILES:
CC(C)(C)N1CCC(=CC1)c1cc(-c2ccc(F)cc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 |c:7,(18.29,-14.38,;16.96,-15.16,;17.74,-16.49,;16.19,-13.83,;15.63,-15.93,;15.63,-17.47,;14.3,-18.24,;12.96,-17.47,;12.96,-15.93,;14.29,-15.16,;11.63,-18.24,;11.63,-19.8,;10.3,-20.57,;10.3,-22.1,;8.96,-22.87,;8.96,-24.41,;10.3,-25.18,;10.3,-26.72,;11.63,-24.4,;11.63,-22.87,;12.96,-22.09,;8.96,-19.8,;7.63,-20.57,;6.29,-19.8,;6.29,-18.25,;4.96,-17.48,;7.63,-17.48,;7.63,-15.95,;6.3,-15.19,;4.97,-15.96,;6.3,-13.65,;7.64,-12.87,;8.97,-13.64,;8.97,-15.18,;10.3,-15.96,;8.96,-18.25,;10.29,-17.48,)|