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Target
Transcriptional enhancer factor TEF-3
Ligand
BDBM50600845
Substrate
n/a
Meas. Tech.
ChEMBL_2235259 (CHEMBL5149031)
Kd
7600±n/a nM
Citation
 Heinrich, T; Peterson, C; Schneider, R; Garg, S; Schwarz, D; Gunera, J; Seshire, A; Kötzner, L; Schlesiger, S; Musil, D; Schilke, H; Doerfel, B; Diehl, P; Böpple, P; Lemos, AR; Sousa, PMF; Freire, F; Bandeiras, TM; Carswell, E; Pearson, N; Sirohi, S; Hooker, M; Trivier, E; Broome, R; Balsiger, A; Crowden, A; Dillon, C; Wienke, D Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead  J Med Chem 65:9206-9229 (2022) [PubMed] 
Target
Name:
Transcriptional enhancer factor TEF-3
Synonyms:
RTEF1 | TCF13L1 | TEA domain family member 4 | TEAD-4 | TEAD4 | TEAD4_HUMAN | TEF3 | Transcription factor 13-like 1 | Transcription factor RTEF-1 | Transcriptional enhancer factor TEF-3
Type:
PROTEIN
Mol. Mass.:
48333.01
Organism:
Homo sapiens
Description:
ChEMBL_118073
Residue:
434
Sequence:
MEGTAGTITSNEWSSPTSPEGSTASGGSQALDKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKDQAAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPGQAGTSHDVKPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWADLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE
  
Inhibitor
Name:
BDBM50600845
Synonyms:
CHEMBL5173440
Type:
Small organic molecule
Emp. Form.:
C17H20F2N2O2
Mol. Mass.:
322.3497
SMILES:
CCCc1nn(C2CCC(F)(F)CC2)c2ccc(cc12)C(O)=O
Structure:
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