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Target
Serine protease inhibitor A3N
Ligand
BDBM50600940
Substrate
n/a
Meas. Tech.
ChEMBL_2235389 (CHEMBL5149161)
EC50
6270±n/a nM
Citation
 Colini Baldeschi, A; Zattoni, M; Vanni, S; Nikolic, L; Ferracin, C; La Sala, G; Summa, M; Bertorelli, R; Bertozzi, SM; Giachin, G; Carloni, P; Bolognesi, ML; De Vivo, M; Legname, G Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance. J Med Chem 65:8998-9010 (2022) [PubMed] 
Target
Name:
Serine protease inhibitor A3N
Synonyms:
SPA3N_MOUSE | Serpin A3N | Serpina3n | Spi2
Type:
PROTEIN
Mol. Mass.:
46713.95
Organism:
Mus musculus
Description:
ChEMBL_120723
Residue:
418
Sequence:
MAFIAALGLLMAGICPAVLCFPDGTLGMDAAVQEDHDNGTQLDSLTLASINTDFAFSLYKELVLKNPDKNIVFSPLSISAALAVMSLGAKGNTLEEILEGLKFNLTETSEADIHQGFGHLLQRLNQPKDQVQISTGSALFIEKRQQILTEFQEKAKTLYQAEAFTADFQQPRQAKKLINDYVRKQTQGMIKELVSDLDKRTLMVLVNYIYFKAKWKVPFDPLDTFKSEFYAGKRRPVIVPMMSMEDLTTPYFRDEELSCTVVELKYTGNASALFILPDQGRMQQVEASLQPETLRKWKNSLKPRMIDELHLPKFSISTDYSLEDVLSKLGIREVFSTQADLSAITGTKDLRVSQVVHKAVLDVAETGTEAAAATGVKFVPMSAKLYPLTVYFNRPFLIMIFDTETEIAPFIAKIANPK
  
Inhibitor
Name:
BDBM50600940
Synonyms:
CHEMBL5081846
Type:
Small organic molecule
Emp. Form.:
C16H17F3N4O2
Mol. Mass.:
354.327
SMILES:
Nc1c(cnn1-c1ccc(OC(F)(F)F)cc1)C(=O)C1CCNCC1
Structure:
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