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Target
B1 bradykinin receptor
Ligand
BDBM50184189
Substrate
n/a
Meas. Tech.
ChEMBL_350972 (CHEMBL858907)
Ki
9.1±n/a nM
Citation
 Kuduk, SD; Di Marco, CN; Chang, RK; Wood, MR; Kim, JJ; Schirripa, KM; Murphy, KL; Ransom, RW; Tang, C; Torrent, M; Ha, S; Prueksaritanont, T; Pettibone, DJ; Bock, MG 5-Piperazinyl pyridine carboxamide bradykinin B1 antagonists. Bioorg Med Chem Lett 16:2791-5 (2006) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50184189
Synonyms:
3,3'-difluoro-4'-[(5-piperidin-1-ylmethyl-pyridin-2-ylamino)-methyl]-biphenyl-2-carboxylic acid methyl ester | CHEMBL208248
Type:
Small organic molecule
Emp. Form.:
C26H27F2N3O2
Mol. Mass.:
451.5083
SMILES:
COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(CN3CCCCC3)cn2)c(F)c1
Structure:
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