Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50603212
Substrate
n/a
Meas. Tech.
ChEMBL_2243440 (CHEMBL5157650)
Ki
170±n/a nM
Citation
 Jonas, H; Aiello, D; Schepmann, D; Diana, P; Wünsch, B Synthesis of 8-aminomorphans with high KOR affinity. Eur J Med Chem 230:0 (2022) [PubMed] 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50603212
Synonyms:
CHEMBL5200121
Type:
Small organic molecule
Emp. Form.:
C18H24Cl2N2O
Mol. Mass.:
355.302
SMILES:
CN(C)[C@@H]1CCC2CCN(C1C2)C(=O)Cc1ccc(Cl)c(Cl)c1 |r,TLB:1:3:11:9.7.8,THB:12:9:3.4.5:11|
Structure:
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