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Target
Kappa-type opioid receptor
Ligand
BDBM50603213
Substrate
n/a
Meas. Tech.
ChEMBL_2243442 (CHEMBL5157652)
Ki
73±n/a nM
Citation
 Jonas, H; Aiello, D; Schepmann, D; Diana, P; Wünsch, B Synthesis of 8-aminomorphans with high KOR affinity. Eur J Med Chem 230:0 (2022) [PubMed] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50603213
Synonyms:
CHEMBL5196638
Type:
Small organic molecule
Emp. Form.:
C19H25Cl2N3O
Mol. Mass.:
382.327
SMILES:
Clc1ccc(CC(=O)N2CCN3CC[C@H](C2C3)N2CCCC2)cc1Cl |r,TLB:17:14:16:8.10.9,THB:6:8:14.13.12:16|
Structure:
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