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Target
Urokinase-type plasminogen activator
Ligand
BDBM50184646
Substrate
n/a
Meas. Tech.
ChEBML_355567
IC50
53±n/a nM
Citation
 Sienczyk, M; Oleksyszyn, J Inhibition of trypsin and urokinase by Cbz-amino(4-guanidinophenyl)methanephosphonate aromatic ester derivatives: the influence of the ester group on their biological activity. Bioorg Med Chem Lett 16:2886-90 (2006) [PubMed]  Article 
Target
Name:
Urokinase-type plasminogen activator
Synonyms:
3.4.21.73 | PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator chain B | Urokinase-type plasminogen activator long chain A | Urokinase-type plasminogen activator short chain A | Urokinase-type plasminogen activator/surface receptor | uPA
Type:
Enzyme
Mol. Mass.:
48528.62
Organism:
Homo sapiens (Human)
Description:
P00749
Residue:
431
Sequence:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
  
Inhibitor
Name:
BDBM50184646
Synonyms:
CHEMBL379814 | [benzyloxycarbonylamino-(4-guanidino-phenyl)-methyl]-phosphonic acid bis-(4-methanesulfonyl-phenyl) ester trifluoro-acetic acid salt
Type:
Small organic molecule
Emp. Form.:
C30H31N4O9PS2
Mol. Mass.:
686.692
SMILES:
[#6]S(=O)(=O)c1ccc(-[#8]P(=O)([#8]-c2ccc(cc2)S([#6])(=O)=O)[#6](-[#7]-[#6](=O)-[#8]-[#6]-c2ccccc2)-c2ccc(cc2)\[#7]=[#6](\[#7])-[#7])cc1
Structure:
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