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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50604542
Substrate
n/a
Meas. Tech.
ChEMBL_2248186 (CHEMBL5162396)
EC50
710±n/a nM
Citation
 Sblano, S; Cerchia, C; Laghezza, A; Piemontese, L; Brunetti, L; Leuci, R; Gilardi, F; Thomas, A; Genovese, M; Santi, A; Tortorella, P; Paoli, P; Lavecchia, A; Loiodice, F A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity. Eur J Med Chem 235:0 (2022) [PubMed] 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50604542
Synonyms:
CHEMBL5203327
Type:
Small organic molecule
Emp. Form.:
C21H25NO4S
Mol. Mass.:
387.493
SMILES:
CC(C)(C)OC(=O)NC(CSCc1ccc(cc1)-c1ccccc1)C(O)=O
Structure:
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