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Target
RNA-directed RNA polymerase
Ligand
BDBM50186192
Substrate
n/a
Meas. Tech.
ChEMBL_366543 (CHEMBL871397)
IC50
756±n/a nM
Citation
 Rockway, TW; Zhang, R; Liu, D; Betebenner, DA; McDaniel, KF; Pratt, JK; Beno, D; Montgomery, D; Jiang, WW; Masse, S; Kati, WM; Middleton, T; Molla, A; Maring, CJ; Kempf, DJ Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring. Bioorg Med Chem Lett 16:3833-8 (2006) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50186192
Synonyms:
1-benzyl-3-(7-bromo-1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1,2,4]thiadiazin-3-yl)-4-hydroxy-1H-[1,8]naphthyridin-2-one | CHEMBL377240
Type:
Small organic molecule
Emp. Form.:
C22H15BrN4O4S
Mol. Mass.:
511.348
SMILES:
Oc1c(C2=Nc3ccc(Br)cc3S(=O)(=O)N2)c(=O)n(Cc2ccccc2)c2ncccc12 |t:3|
Structure:
Search PDB for entries with ligand similarity: