Reaction Details
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Muscarinic acetylcholine receptor M5
Ligand
BDBM50605085
Substrate
n/a
Meas. Tech.
ChEMBL_2250306 (CHEMBL5164516)
IC50
35±n/a nM
Citation
Garrison, AT; Orsi, DL; Capstick, RA; Whomble, D; Li, J; Carter, TR; Felts, AS; Vinson, PN; Rodriguez, AL; Han, A; Hajari, K; Cho, HP; Teal, LB; Ragland, MG; Ghamari-Langroudi, M; Bubser, M; Chang, S; Schnetz-Boutaud, NC; Boutaud, O; Blobaum, AL; Foster, DJ; Niswender, CM; Conn, PJ; Lindsley, CW; Jones, CK; Han, C Development of J Med Chem 65:6273-6286 (2022) [PubMed] More Info.:
Target
Name:
Muscarinic acetylcholine receptor M5
Synonyms:
ACM5_HUMAN | CHRM5
Type:
PROTEIN
Mol. Mass.:
60102.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1517990
Residue:
532
Sequence:
MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
Inhibitor
Name:
BDBM50605085
Synonyms:
CHEMBL5204021
Type:
Small organic molecule
Emp. Form.:
C18H22FN3O3S2
Mol. Mass.:
411.514
SMILES:
Cn1ccnc1SC[C@H]1CCN(C[C@@H]1F)S(=O)(=O)c1ccc2OCCc2c1 |r|
Structure:
