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Target
Target of rapamycin complex 2 subunit MAPKAP1
Ligand
BDBM582478
Substrate
n/a
Meas. Tech.
ChEMBL_2261205 (CHEMBL5216216)
IC50
11±n/a nM
Citation
 Oleksak, P; Nepovimova, E; Chrienova, Z; Musilek, K; Patocka, J; Kuca, K Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015-2021). Eur J Med Chem 238:0 (2022) [PubMed] 
Target
Name:
Target of rapamycin complex 2 subunit MAPKAP1
Synonyms:
MAPKAP1 | MIP1 | Mitogen-activated protein kinase 2-associated protein 1 | SAPK-interacting protein 1 | SIN1 | SIN1_HUMAN | Stress-activated map kinase-interacting protein 1 | TORC2 subunit MAPKAP1 | Target of rapamycin complex 2 subunit MAPKAP1 | mSIN1
Type:
PROTEIN
Mol. Mass.:
59129.70
Organism:
Human
Description:
ChEMBL_119716
Residue:
522
Sequence:
MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGETQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQELKSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKVSGPQYRLEKQSEPNVAVDLDSTLESQSAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
  
Inhibitor
Name:
BDBM582478
Synonyms:
5-(2-aminobenzoxazol-5-yl)-7-isobutyl-6, 7-dihydro-5H-pyrrolo[3,2-d]pyrimidin-4-ylamine | US11518767, Example 3
Type:
Small organic molecule
Emp. Form.:
C17H20N6O
Mol. Mass.:
324.3803
SMILES:
CC(C)CC1CN(c2c1ncnc2N)c1ccc2oc(N)nc2c1
Structure:
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