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Target
TGF-beta receptor type-1
Ligand
BDBM50405402
Substrate
n/a
Meas. Tech.
ChEMBL_2265106
IC50
3.0±n/a nM
Citation
 Pujala, B; Ramachandran, SA; Sonawane, M; Kamble, MM; Panpatil, D; Adhikari, S; Soni, S; Subbareddy, V; Shinde, BU; Nayak, AK; Bansal, C; Gupta, A; Mukherjee, K; Agarwal, AK; Guerrero, J; Herrera, FJ; Bernales, S; Guha, M; Chakravarty, S; Pham, SM; Rai, R Discovery of MDV6058 (PF-06952229), a selective and potent TGF?R1 inhibitor: Design, synthesis and optimization. Bioorg Med Chem Lett 75:0 (2022) [PubMed] 
Target
Name:
TGF-beta receptor type-1
Synonyms:
ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I
Type:
enzyme
Mol. Mass.:
55968.24
Organism:
Homo sapiens (Human)
Description:
P36897
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM50405402
Synonyms:
CHEMBL5267945
Type:
Small organic molecule
Emp. Form.:
C20H18ClFN4O
Mol. Mass.:
384.835
SMILES:
CC(C)c1cnc(cc1Nc1ccncc1C(N)=O)-c1cc(Cl)ccc1F
Structure:
Search PDB for entries with ligand similarity: