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Target
REST corepressor 1
Ligand
BDBM50410789
Substrate
n/a
Meas. Tech.
ChEMBL_2268622
IC50
7.2±n/a nM
Citation
 Matsuda, S; Hattori, Y; Matsumiya, K; McQuade, P; Yamashita, T; Aida, J; Sandiego, CM; Gouasmat, A; Carroll, VM; Barret, O; Tamagnan, G; Koike, T; Kimura, H Design, Synthesis, and Evaluation of [ J Med Chem 64:12680-12690 (2021) [PubMed] 
Target
Name:
REST corepressor 1
Synonyms:
KIAA0071 | Protein CoREST | RCOR | RCOR1 | RCOR1_HUMAN | REST corepressor 1
Type:
PROTEIN
Mol. Mass.:
53329.34
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108118
Residue:
485
Sequence:
MPAMVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQKREREESEDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLDVRYASAS
  
Inhibitor
Name:
BDBM50410789
Synonyms:
CHEMBL5277056
Type:
Small organic molecule
Emp. Form.:
C20H22FN3O
Mol. Mass.:
339.4066
SMILES:
Cc1cc(F)ncc1C(=O)Nc1ccc(cc1)[C@@H]1C[C@H]1NCC1CC1 |r|
Structure:
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