Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50194829
Substrate
n/a
Meas. Tech.
ChEMBL_424571 (CHEMBL853922)
IC50
2.3±n/a nM
Citation
 Swain, CJ; Teran, A; Maroto, M; Cabello, A Identification and optimisation of 5-amino-7-aryldihydro-1,4-diazepines as 5-HT2A ligands. Bioorg Med Chem Lett 16:6058-62 (2006) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52852.05
Organism:
Rattus norvegicus (rat)
Description:
Rat cortex membranes 5-HT2A receptors.
Residue:
471
Sequence:
MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
  
Inhibitor
Name:
BDBM50194829
Synonyms:
7-(2,4-difluorophenyl)-N-(1-ethylcyclopentyl)-2,3-dihydro-1H-1,4-diazepin-5-amine | CHEMBL373966
Type:
Small organic molecule
Emp. Form.:
C18H23F2N3
Mol. Mass.:
319.3921
SMILES:
CCC1(CCCC1)N=C1CC(=NCCN1)c1ccc(F)cc1F |w:7.7,c:11|
Structure:
Search PDB for entries with ligand similarity: