Reaction Details Report a problem with these data
Target
Plasmepsin II
Ligand
BDBM50195415
Substrate
n/a
Meas. Tech.
ChEMBL_424955 (CHEMBL911362)
IC50
165±n/a nM
Citation
Corminboeuf, O; Dunet, G; Hafsi, M; Grimont, J; Grisostomi, C; Meyer, S; Binkert, C; Bur, D; Jones, A; Prade, L; Brun, R; Boss, C Inhibitors of Plasmepsin II-potential antimalarial agents. Bioorg Med Chem Lett 16:6194-9 (2006) [PubMed] Article
More Info.:
Target
Name:
Plasmepsin II
Synonyms:
Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II
Type:
Enzyme
Mol. Mass.:
51482.09
Organism:
Plasmodium falciparum
Description:
P46925
Residue:
453
Sequence:
MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYENVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKTNYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
Inhibitor
Name:
BDBM50195415
Synonyms:
CHEMBL375351 | N-(4-(benzo[d][1,3]dioxol-5-yl)benzyl)-4-pentyl-N-(2-(4-(3-phenylpropyl)piperidin-1-yl)ethyl)benzamide
Type:
Small organic molecule
Emp. Form.:
C42H50N2O3
Mol. Mass.:
630.858
SMILES:
CCCCCc1ccc(cc1)C(=O)N(CCN1CCC(CCCc2ccccc2)CC1)Cc1ccc(cc1)-c1ccc2OCOc2c1