Reaction Details Report a problem with these data
Target
Plasmepsin II
Ligand
BDBM50195407
Substrate
n/a
Meas. Tech.
ChEMBL_424955 (CHEMBL911362)
IC50
74±n/a nM
Citation
 Corminboeuf, O; Dunet, G; Hafsi, M; Grimont, J; Grisostomi, C; Meyer, S; Binkert, C; Bur, D; Jones, A; Prade, L; Brun, R; Boss, C Inhibitors of Plasmepsin II-potential antimalarial agents. Bioorg Med Chem Lett 16:6194-9 (2006) [PubMed]  Article 
Target
Name:
Plasmepsin II
Synonyms:
Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II
Type:
Enzyme
Mol. Mass.:
51482.09
Organism:
Plasmodium falciparum
Description:
P46925
Residue:
453
Sequence:
MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYENVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKTNYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
  
Inhibitor
Name:
BDBM50195407
Synonyms:
CHEMBL207616 | N-(2-dibutylamino-ethyl)-N-[4'-(2-morpholin-4-yl-2-oxo-ethyl)-biphenyl-4-ylmethyl]-4-pentyl-benzamide
Type:
Small organic molecule
Emp. Form.:
C41H57N3O3
Mol. Mass.:
639.9096
SMILES:
CCCCCc1ccc(cc1)C(=O)N(CCN(CCCC)CCCC)Cc1ccc(cc1)-c1ccc(CC(=O)N2CCOCC2)cc1
Structure:
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