Reaction Details Report a problem with these data
Target
Plasmepsin II
Ligand
BDBM50195383
Substrate
n/a
Meas. Tech.
ChEMBL_424955 (CHEMBL911362)
IC50
531±n/a nM
Citation
 Corminboeuf, O; Dunet, G; Hafsi, M; Grimont, J; Grisostomi, C; Meyer, S; Binkert, C; Bur, D; Jones, A; Prade, L; Brun, R; Boss, C Inhibitors of Plasmepsin II-potential antimalarial agents. Bioorg Med Chem Lett 16:6194-9 (2006) [PubMed]  Article 
Target
Name:
Plasmepsin II
Synonyms:
Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II
Type:
Enzyme
Mol. Mass.:
51482.09
Organism:
Plasmodium falciparum
Description:
P46925
Residue:
453
Sequence:
MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYENVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKTNYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
  
Inhibitor
Name:
BDBM50195383
Synonyms:
CHEMBL221149 | N-(4-(pyrimidin-5-yl)benzyl)-N-(2-(dibutylamino)ethyl)-4-pentylbenzamide
Type:
Small organic molecule
Emp. Form.:
C33H46N4O
Mol. Mass.:
514.7445
SMILES:
CCCCCc1ccc(cc1)C(=O)N(CCN(CCCC)CCCC)Cc1ccc(cc1)-c1cncnc1
Structure:
Search PDB for entries with ligand similarity: