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Target
Dihydrofolate reductase
Ligand
BDBM50051915
Substrate
n/a
Meas. Tech.
ChEMBL_2272782
IC50
8500±n/a nM
Citation
 Wu, RZ; Zhou, HY; Song, JF; Xia, QH; Hu, W; Mou, XD; Li, X Chemotherapeutics for  J Med Chem 64:17627-17655 (2021) [PubMed] 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM50051915
Synonyms:
CHEMBL32708 | N*6*-(2,5-Dimethoxy-benzyl)-pyrido[2,3-d]pyrimidine-2,4,6-triamine | N6-(2,5-dimethoxybenzyl)pyrido[2,3-d]pyrimidine-2,4,6-triamine
Type:
Small organic molecule
Emp. Form.:
C16H18N6O2
Mol. Mass.:
326.3531
SMILES:
COc1ccc(OC)c(CNc2cnc3nc(N)nc(N)c3c2)c1
Structure:
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