Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM50608146
Substrate
n/a
Meas. Tech.
ChEMBL_2272791
IC50
12±n/a nM
Citation
 Wu, RZ; Zhou, HY; Song, JF; Xia, QH; Hu, W; Mou, XD; Li, X Chemotherapeutics for  J Med Chem 64:17627-17655 (2021) [PubMed] 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50608146
Synonyms:
CHEMBL5281180
Type:
Small organic molecule
Emp. Form.:
C11H14N4O3
Mol. Mass.:
250.2539
SMILES:
C[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1c[nH]c2c1nc[nH]c2=O |r|
Structure:
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