Reaction Details Report a problem with these data
Target
Monoacylglycerol lipase ABHD6
Ligand
BDBM50608631
Substrate
n/a
Meas. Tech.
ChEMBL_2274342
IC50
2.0±n/a nM
Citation
 Deng, H; Li, W Therapeutic potential of targeting ?/?-Hydrolase domain-containing 6 (ABHD6). Eur J Med Chem 198:0 (2020) [PubMed] 
Target
Name:
Monoacylglycerol lipase ABHD6
Synonyms:
2-arachidonoylglycerol hydrolase | ABHD6 | ABHD6_HUMAN | Abhydrolase domain-containing protein 6 | Monoacylglycerol lipase ABHD6
Type:
PROTEIN
Mol. Mass.:
38341.83
Organism:
Human
Description:
ChEMBL_105457
Residue:
337
Sequence:
MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYVHHEDYQFCYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLSIDGQVKRIHQFVECLKLNKKPFHLVGTSMGGQVAGVYAAYYPSDVSSLCLVCPAGLQYSTDNQFVQRLKELQGSAAVEKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHNNFYRKLFLEIVSEKSRYSLHQNMDKIKVPTQIIWGKQDQVLDVSGADMLAKSIANCQVELLENCGHSVVMERPRKTAKLIIDFLASVHNTDNNKKLD
  
Inhibitor
Name:
BDBM50608631
Synonyms:
CHEMBL5274434
Type:
Small organic molecule
Emp. Form.:
C25H26F3N5O4
Mol. Mass.:
517.5002
SMILES:
CC(C)(C)OC(=O)N1CCN(C(C1)c1ccccc1)C(=O)n1cc(nn1)-c1ccc(OC(F)(F)F)cc1
Structure:
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