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Target
Proprotein convertase subtilisin/kexin type 9
Ligand
BDBM50609097
Substrate
n/a
Meas. Tech.
ChEMBL_2276374
Kd
1.000000±n/a nM
Citation
 Ahamad, S; Bhat, SA Recent Update on the Development of PCSK9 Inhibitors for Hypercholesterolemia Treatment. J Med Chem 65:15513-15539 (2022) [PubMed] 
Target
Name:
Proprotein convertase subtilisin/kexin type 9
Synonyms:
3.4.21.- | NARC-1 | Narc1 | Neural apoptosis-regulated convertase 1 | PC9 | Pcsk9 | Proprotein convertase 9 | Proprotein convertase subtilisin/kexin type 9 | Subtilisin/kexin-like protease PC9
Type:
PROTEIN
Mol. Mass.:
74829.40
Organism:
Mouse
Description:
ChEMBL_120881
Residue:
694
Sequence:
MGTHCSAWLRWPLLPLLPPLLLLLLLLCPTGAGAQDEDGDYEELMLALPSQEDGLADEAAHVATATFRRCSKEAWRLPGTYIVVLMEETQRLQIEQTAHRLQTRAARRGYVIKVLHIFYDLFPGFLVKMSSDLLGLALKLPHVEYIEEDSFVFAQSIPWNLERIIPAWHQTEEDRSPDGSSQVEVYLLDTSIQGAHREIEGRVTITDFNSVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGTSLHSLRVLNCQGKGTVSGTLIGLEFIRKSQLIQPSGPLVVLLPLAGGYSRILNAACRHLARTGVVLVAAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGKDIIGASSDCSTCFMSQSGTSQAAAHVAGIVARMLSREPTLTLAELRQRLIHFSTKDVINMAWFPEDQQVLTPNLVATLPPSTHETGGQLLCRTVWSAHSGPTRTATATARCAPEEELLSCSSFSRSGRRRGDWIEAIGGQQVCKALNAFGGEGVYAVARCCLVPRANCSIHNTPAARAGLETHVHCHQKDHVLTGCSFHWEVEDLSVRRQPALRSRRQPGQCVGHQAASVYASCCHAPGLECKIKEHGISGPSEQVTVACEAGWTLTGCNVLPGASLTLGAYSVDNLCVARVHDTARADRTSGEATVAAAICCRSRPSAKASWVQ
  
Inhibitor
Name:
BDBM50609097
Synonyms:
CHEMBL5271747
Type:
Small organic molecule
Emp. Form.:
C85H112N18O20S
Mol. Mass.:
1737.972
SMILES:
[H][C@@]12CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)N(C)C(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)[C@H](C)N(C)C(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CSC[C@H](NC2=O)C(=O)NCC(N)=O)C(C)C)[C@@H](C)O)[C@@H](C)O |r|
Structure:
Search PDB for entries with ligand similarity: