Reaction Details Report a problem with these data
Target
Protein arginine N-methyltransferase 8
Ligand
BDBM50609300
Substrate
n/a
Meas. Tech.
ChEMBL_2277374
IC50
920±n/a nM
Citation
 Zhang, Z; Guo, Z; Xu, X; Cao, D; Yang, H; Li, Y; Shi, Q; Du, Z; Guo, X; Wang, X; Chen, D; Zhang, Y; Chen, L; Zhou, K; Li, J; Geng, M; Huang, X; Xiong, B Structure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy. J Med Chem 64:16650-16674 (2021) [PubMed] 
Target
Name:
Protein arginine N-methyltransferase 8
Synonyms:
ANM8_HUMAN | HRMT1L3 | HRMT1L3 | HRMT1L4 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4 | PRMT8 | Protein arginine N-methyltransferase 8 | Protein arginine N-methyltransferase 8 (PRMT8) | Protein arginine methyltransferase 8 (PRMT8)
Type:
Protein
Mol. Mass.:
45293.70
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
394
Sequence:
MGMKHSSRCLLLRRKMAENAAESTEVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLCETSVSNDYKMR
  
Inhibitor
Name:
BDBM50609300
Synonyms:
CHEMBL5266562
Type:
Small organic molecule
Emp. Form.:
C26H30N6O
Mol. Mass.:
442.556
SMILES:
CNCCNCc1cccc(c1)-c1nc(Nc2ccccc2)c(C)c(n1)-c1c(C)noc1C |(3.97,-25.93,;5.31,-25.16,;6.64,-25.93,;7.97,-25.16,;9.31,-25.93,;10.64,-25.16,;11.98,-25.93,;11.97,-27.48,;13.31,-28.25,;14.64,-27.48,;14.64,-25.92,;13.3,-25.16,;15.97,-25.15,;15.96,-23.62,;17.28,-22.84,;17.27,-21.3,;18.6,-20.52,;19.93,-21.29,;21.26,-20.51,;21.25,-18.97,;19.9,-18.21,;18.58,-18.99,;18.63,-23.61,;19.96,-22.83,;18.63,-25.15,;17.3,-25.92,;19.96,-25.91,;21.36,-25.27,;21.67,-23.76,;22.39,-26.41,;21.63,-27.74,;20.13,-27.43,;18.99,-28.46,)|
Structure:
Search PDB for entries with ligand similarity: