Reaction Details Report a problem with these data
Target
Protein kinase C delta type
Ligand
BDBM50612016
Substrate
n/a
Meas. Tech.
ChEMBL_2285514
Ki
0.110000±n/a nM
Citation
 Xu, J; Zhang, T; Yao, J; Lu, J; Liu, Z; Ding, L Recent advances in chemistry and bioactivity of marine cyanobacteria Moorea species. Eur J Med Chem 201:0 (2020) [PubMed] 
Target
Name:
Protein kinase C delta type
Synonyms:
KPCD_HUMAN | PKC delta | PKCD | PRKCD | Protein Kinase C- delta | Protein kinase C, PKC; classical/novel | nPKC-delta
Type:
Enzyme
Mol. Mass.:
77516.79
Organism:
Homo sapiens (Human)
Description:
The recombinant human PKC enzymes were produced using a baculovirus expression system in SF9 cells
Residue:
676
Sequence:
MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEHLLED
  
Inhibitor
Name:
BDBM50612016
Synonyms:
CHEMBL5172923
Type:
Small organic molecule
Emp. Form.:
C27H39N3O2
Mol. Mass.:
437.6175
SMILES:
CC(C)[C@@H]1N(C)c2ccc(c3[nH]cc(C[C@@H](CO)NC1=O)c23)[C@](C)(CCC=C(C)C)C=C |r,wU:3.2,wD:15.15,22.25,(-1.31,3.86,;.18,4.26,;.57,5.74,;1.26,3.17,;.49,1.84,;-.99,2.24,;.75,.32,;-.7,-.21,;-.95,-1.73,;.22,-2.71,;1.67,-2.18,;3.03,-2.9,;4.13,-1.84,;3.49,-.67,;4.67,.31,;4.93,1.83,;6.42,2.23,;6.82,3.71,;4.17,3.15,;2.72,3.69,;2.72,5.23,;1.94,-.67,;-.17,-4.2,;-.17,-5.74,;-1.66,-4.6,;-2.75,-3.51,;-4.24,-3.91,;-5.33,-2.82,;-6.82,-3.22,;-4.93,-1.33,;1.16,-4.97,;2.49,-4.2,)|
Structure:
Search PDB for entries with ligand similarity: