Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM50612782
Substrate
n/a
Meas. Tech.
ChEMBL_2289803
Ki
23±n/a nM
Citation
 Tolentino, KT; Mashinson, V; Sharma, MK; Chhonker, YS; Murry, DJ; Hopkins, CR From dopamine 4 to sigma 1: Synthesis, SAR and biological characterization of a piperidine scaffold of ?1 modulators. Eur J Med Chem 244:0 (2022) [PubMed] 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
MAC30 | Meningioma-associated protein 30 | S2R | SGMR2_HUMAN | Sigma-2 receptor | Sigma2 receptor | TMEM97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20857.20
Organism:
Homo sapiens (Human)
Description:
Q5BJF2
Residue:
176
Sequence:
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
  
Inhibitor
Name:
BDBM50612782
Synonyms:
CHEMBL5269586
Type:
Small organic molecule
Emp. Form.:
C22H24F2N4
Mol. Mass.:
382.4496
SMILES:
Fc1ccc(CN2CCCC22CCN(Cc3cn4ccccc4n3)C2)cc1F
Structure:
Search PDB for entries with ligand similarity: