Reaction Details Report a problem with these data
Target
Sodium channel subunit beta-2
Ligand
BDBM145285
Substrate
n/a
Meas. Tech.
ChEMBL_2291912
IC50
0.400000±n/a nM
Citation
 Karanjule, N; Hayashi, N; Suzuki, S; Tsuda, T; Tokumaru, E; Tanaka, K; Kimoto, H; Domon, Y; Takahashi, S; Kubota, K; Kitano, Y; Yokoyama, T; Koishi, R; Fujiwara, C; Inaba, S; Asano, D; Sakakura, T; Takasuna, K; Shinozuka, T -Aryl Indoles as a Novel Class of Potent Na ACS Med Chem Lett 14:788-793 (2023) [PubMed] 
Target
Name:
Sodium channel subunit beta-2
Synonyms:
SCN2B | SCN2B_HUMAN | Sodium channel subunit beta-2
Type:
PROTEIN
Mol. Mass.:
24325.09
Organism:
Homo sapiens
Description:
ChEMBL_119884
Residue:
215
Sequence:
MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTVPATLNVLNGSDARLPCTFNSCYTVNHKQFSLNWTYQECNNCSEEMFLQFRMKIINLKLERFQDRVEFSGNPSKYDVSVMLRNVQPEDEGIYNCYIMNPPDRHRGHGKIHLQVLMEEPPERDSTVAVIVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKTDGEGNPDDGAK
  
Inhibitor
Name:
BDBM145285
Synonyms:
US8952169, 64 | US9771376, Example 64
Type:
Small organic molecule
Emp. Form.:
C24H31FN2O4S
Mol. Mass.:
462.577
SMILES:
Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 |TLB:5:6:9:13.12.11,15:6:13:9.10.11,THB:15:10:13:6.14.7,14:6:9:13.12.11,14:12:9:6.15.7|
Structure:
Search PDB for entries with ligand similarity: