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Target
Ribonuclease SLFN12
Ligand
BDBM50614155
Substrate
n/a
Meas. Tech.
ChEMBL_2295911
Kd
65±n/a nM
Citation
 Meanwell, NA Anagrelide: A Clinically Effective cAMP Phosphodiesterase 3A Inhibitor with Molecular Glue Properties. ACS Med Chem Lett 14:350-361 (2023) [PubMed] 
Target
Name:
Ribonuclease SLFN12
Synonyms:
3.1.-.- | Ribonuclease SLFN12 | SLFN12 | Schlafen family member 12
Type:
PROTEIN
Mol. Mass.:
66989.91
Organism:
Human
Description:
ChEMBL_120910
Residue:
578
Sequence:
MNISVDLETNYAELVLDVGRVTLGENSRKKMKDCKLRKKQNESVSRAMCALLNSGGGVIKAEIENEDYSYTKDGIGLDLENSFSNILLFVPEYLDFMQNGNYFLIFVKSWSLNTSGLRITTLSSNLYKRDITSAKVMNATAALEFLKDMKKTRGRLYLRPELLAKRPCVDIQEENNMKALAGVFFDRTELDRKEKLTFTESTHVEIKNFSTEKLLQRIKEILPQYVSAFANTDGGYLFIGLNEDKEIIGFKAEMSDLDDLEREIEKSIRKMPVHHFCMEKKKINYSCKFLGVYDKGSLCGYVCALRVERFCCAVFAKEPDSWHVKDNRVMQLTRKEWIQFMVEAEPKFSSSYEEVISQINTSLPAPHSWPLLEWQRQRHHCPGLSGRITYTPENLCRKLFLQHEGLKQLICEEMDSVRKGSLIFSRSWSVDLGLQENHKVLCDALLISQDSPPVLYTFHMVQDEEFKGYSTQTALTLKQKLAKIGGYTKKVCVMTKIFYLSPEGMTSCQYDLRSQVIYPESYYFTRRKYLLKALFKALKRLKSLRDQFSFAENLYQIIGIDCFQKNDKKMFKSCRRLT
  
Inhibitor
Name:
BDBM50614155
Synonyms:
CHEMBL4247714
Type:
Small organic molecule
Emp. Form.:
C15H20N4O3
Mol. Mass.:
304.3443
SMILES:
CCN(CC)c1ccc(cc1[N+]([O-])=O)C1=NNC(=O)C[C@H]1C |r,t:15|
Structure:
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